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Schematic illustration of activated and inhibited Wnt/β-catenin pathway. “WNT ON condition�? Upon ligation of Wnts to their receptors composed of frizzled proteins and LRP5/six, the cytoplasmic protein DVL is activated and induces the suppression of GSK3β. Subsequently, stabilized β-catenin translocates into your nucleus and binds to TCF/LEF